This quote emphasizes the inherent resistance to change that is part of human nature. It suggests that when a person attempts to bring about change, it often results in conflict or opposition, hence making ‘enemies’. This is because change tends to disrupt the status quo, challenge existing norms and beliefs, and push people out of their comfort zones.

In terms of depth, the quote also alludes to the idea that change is not just difficult, but also potentially isolating. As the instigator of change, one may have to face opposition alone, which can be a daunting prospect. This reflects the courage and determination required to effect change, suggesting that it is often a path fraught with challenges and resistance.

Applying this idea to today’s world, we can see it in action in various spheres. For instance, in politics, leaders who attempt to implement new policies or reforms often face backlash from those who prefer the existing system or have vested interests in maintaining it. In the corporate world, managers or CEOs who try to change company culture or business strategies may face resistance from employees who are comfortable with the way things are.

In the realm of personal development, this quote can be interpreted as a reminder that growth and progress often involve change, which can be uncomfortable and meet with resistance, both from within ourselves and from others. Whether it’s trying to break a bad habit, learn a new skill, or make a significant life change, the process can be challenging and may even lead to conflicts with others who are used to our old ways. However, the quote also implicitly encourages persisting with the change, as the end result could lead to personal growth and improvement.

In conclusion, this quote is a profound observation of the human condition and our relationship with change. It offers a realistic view of the challenges involved in effecting change, while also encouraging the courage and determination needed to overcome them.