This quote suggests that progress and innovation often come from those who are seen as different, non-conformist, or even controversial. The terms "bigots", "eccentrics", "cranks", and "heretics" are used to describe individuals who deviate from the norm in their beliefs, behavior, or thinking. These people often challenge accepted norms and conventions, which can lead to new ideas and progress.

"Bigots" in this context doesn’t necessarily refer to people with prejudiced beliefs, but rather individuals who hold strongly to their own ideas and principles, sometimes to the point of stubbornness. "Eccentrics" and "cranks" are those who are seen as odd or strange, whose unconventional ways of thinking often lead to novel ideas. "Heretics" refers to those who go against established beliefs or doctrines, often sparking debates that lead to new insights.

In today’s world, this idea can be seen in various fields, from technology and science to art and philosophy. Many groundbreaking innovations and discoveries have come from people who were initially seen as eccentric or heretical. For example, individuals who first proposed ideas like the Earth revolving around the Sun, or the concept of evolution, were seen as heretics in their time. Yet, these ideas have fundamentally changed our understanding of the world.

In terms of personal development, this quote suggests the importance of embracing one’s uniqueness and not being afraid to challenge conventional wisdom. It encourages individuals to hold firmly to their beliefs, even if they are not popular, and to dare to think differently. This mindset can lead to personal growth and can also contribute to societal progress. After all, it is often those who dare to think differently who end up changing the world.