This quote suggests that the effectiveness of any ministry, or religious service, is dependent not on human effort alone but on the influence of a higher power – in this case, referred to as the Spirit of God. The “spirits of men” refers to their inner beings or souls. Essentially, it underscores the belief that true transformation and enlightenment come from divine intervention acting upon human spirit.

The phrase “All the hope” emphasizes total dependence on this divine influence. It implies that without it, there would be no hope for success in any spiritual endeavor. This idea resonates with many religious teachings which emphasize surrendering to a higher power and allowing it to guide one’s actions and decisions.

Applying this concept in today’s world can be seen in various contexts beyond just religion or spirituality. In personal development terms, for example, “the Spirit of God operating on spirits of men” could symbolize an external force or circumstance prompting introspection and personal growth.

For instance, an individual may go through a life-changing event like losing a job or experiencing a health crisis. These events could act as ‘the Spirit’ that pushes them towards self-evaluation (operation on their ‘spirit’). As they navigate through these challenges (akin to divine intervention), they might discover resilience they didn’t know they had or develop skills they wouldn’t have otherwise acquired.

In essence, just like Spurgeon suggests relying on divine guidance for successful ministry work; similarly individuals can rely upon life’s challenging circumstances as catalysts for personal growth and transformation – thus applying his perspective into modern-day context.