This quote suggests that the greatest obstacle to the advancement of thought and ideas is an attitude of partisan hostility. In other words, when people are overly committed to their own group or party, to the point of being irritable or hostile towards others, it can prevent new and innovative thoughts from emerging.

The phrase “irritated party-spirit” refers to the kind of blind loyalty and fierce partisanship that can lead to hostility and division. This attitude can create an environment where people are more focused on defending their own positions or attacking others, rather than engaging in open, thoughtful discussion. This can stifle creativity and innovation, and prevent us from exploring new ideas or perspectives.

In today’s world, we can see this idea illustrated in many areas, from politics to social media. When people become entrenched in their own viewpoints and refuse to consider others, it can lead to a breakdown in communication and understanding. This can prevent progress and make it difficult to find solutions to complex problems.

In terms of personal development, this quote suggests that it’s important to remain open to new ideas and perspectives, rather than becoming overly attached to our own views. By doing so, we can foster a more inclusive and open-minded mindset, which can facilitate personal growth and learning. It encourages us to be more accepting and understanding of others, rather than being defensive or hostile.

In conclusion, this quote is a reminder of the importance of maintaining an open mind, and the dangers of letting partisan hostility get in the way of progress and innovation. It suggests that we should strive to foster an environment where diverse ideas and perspectives are welcomed and valued, rather than dismissed or attacked.